孙涛 教授

电子邮箱:taosun@hqu.edu.cn

-

特聘教授、学科带头人

福建省“百人计划”特聘专家

厦门市“双百计划”创业人才,泉州市“桐江学者”

华侨大学,生物医学学院、太阳成集团tyc234cc

福建省厦门市,361021

-研究方向

• 干细胞、神经干细胞发育和神经再生

• 神经系统发育和人类神经、精神疾病的遗传机制

• 非编码RNA的基因治疗及精准医学研究

-教育背景

09/1995—11/1999 神经生物学博士

                 伦敦大学学院 (University College London, London, UK)

                 MRC分子细胞生物实验室

               导师: William D. Richardson

09/1991—07/1994 动物学硕士

               中国科学院动物所 (北京)

09/1987—07/1991 动物学学士

                  厦门大学生物系 (厦门)

-工作经历

2017至今 华侨大学“精准医疗研究中心”主任

2016—2017 特聘教授,院长,学科带头人

            华侨大学,生物医学学院、太阳成集团tyc234cc。 福建,泉州

2011—2016 教授

            康奈尔大学威尔太阳成集团tyc234cc (Cornell University Weill Medical College, New York, USA)

            细胞与发育生物学系

2005—2011 助理教授

            康奈尔大学威尔太阳成集团tyc234cc (Cornell University Weill Medical College, New York, USA)

           细胞与发育生物学系

2002—2005 博士后

            哈佛大学太阳成集团tyc234cc (Harvard Medical school, Boston, USA)

            BIDMC医学中心神经生物学系

            导师: Christopher A. Walsh

2000—2002 博士后

            哈佛大学太阳成集团tyc234cc (Harvard Medical school, Boston, USA)

            Dana-Farber癌症研究所小儿肿瘤科

            导师: David Rowitch, Chuck Stiles

-荣誉

1991 厦门大学最佳毕业生奖,厦门

1992 中国科学院动物所最佳毕业生奖,北京

1995 中国医科院杰出青年奖,北京

2001-2004 National Multiple Sclerosis Society杰出博士后奖, USA

2004-2005 哈佛大学太阳成集团tyc234cc博士后训练基金, Boston, USA

2007-2010 Whitehall Foundation科研奖, USA

2008-2009 Bohmfalk 科研奖, USA

2008-2012 The Ellison Medical Foundation 杰出青年奖, USA

2010-2013 Qatar Foundation 科研奖, Qatar

2011-2016 Irma T. Hirschl 科研奖, USA

2017 福建省“百人计划”特聘专家

2017 福建省厦门市“双百计划”创业人才

2017 福建省泉州市“桐江学者”特聘教授,泉州市二类人才认定

-重要科研成就

· 利用单细胞测序技术,揭示了人类大脑中间神经元发育规律,研究成果于2021年发表在“Nature Neuroscience”上。

· 入选爱思唯尔(Elsevier)发布的2021年中国高被引学者(Highly Cited Chinese Researchers)榜单。

· 率先筛选了人类胚胎大脑不对称表达基因。此工作发表在"Science"杂志上。此文被引用250余次。

· 首次建立了微型RNA sponge转基因小鼠, 发表于“Cell Reports”。

· 率先建立了用人类PDGFRa YAC DNA的转基因小鼠。

-学术会籍

2003-至今 神经科学学会 (Society for Neuroscience, USA)

1999-2001 发育生物学学会 (Society for Developmental Biology, USA)

1997-2001 英国细胞生物学学会 (British Society for Cell Biology, UK)

1996-1999 伦敦大学学院人类遗传学中心 (Centre for Human Genetics at the University College London, UK)

-​研究资助

中国国家自然科学基金面上项目.

# 32271002:54万; 2023.01—2026.12.

研究大脑皮层下区中间神经元祖细胞和前体细胞发育的分子机制

Role: 课题第一负责人.


• 中国国家自然科学基金面上项目.

#31771141:60万; 2017.10—2021.12.

长链非编码RNA调控大脑皮层神经干细胞分化的分子机制

Role: 课题第一负责人.


• National Institute of Health (NIH), NIMH.

R01MH083680: $250,000 per year; total: $1,250,000. 04/23/2009—02/28/2019.

MicroRNA Function in the Development of the Cerebral Cortex.

Role: PI.


• Qatar National Research Fund, Qatar Foundation

Total: $366,000. $122,000 per year. 09/2010--09/2013.

Epigenetic control of odorant receptor gene choice

Role: Co-PI.


• Irma T. Hirschl Award

Total: $175,000. $35,000 per year. 01/2011--01/2016.

Non-coding RNA functions in motor neuron development

Role: PI.


• T32 NIH Training Grant at Children’s Hospital, Harvard Medical School 7/1/04—7/1/05 Identify differentially expressed genes in the human fetal cerebral cortex.


· Advanced Postdoctoral Fellowship Award, National Multiple Sclerosis Society

7/1/01--7/1/04 Molecular regulation of cell fate determination in the neural tube.


• The Bohmfalk Award

Total: $37,500. 06/2008—06/2009.

Molecular regulation of asymmetric cortical development

Role: PI.


• Whitehall Foundation Research Grant

Total: $225,000. $75,000 per year. 08/2007--08/2010.

Molecular control of the motor cortex size and motor coordination.


• Gladys and Roland Harriman Foundation

Total: $21,000. 01/2010--01/2011.

Molecular control of the anterior-posterior cortical patterning

Role: PI.


• Ellison Medical Foundation New Scholars Award

Total: $400,000. $100,000 per year. 08/2008—08/2012.

MicroRNA function in maintaining neural stem cells in the aging brain

Role: PI.

-大学委员会

2008-2010 康奈尔大学威尔医学研究生院招生录取委员会

-教学

华侨大学:

2016—present “现代生物学进展”(生物医学学院研究生课程)

2017—present “人类健康与现代生物医学研究”(华侨大学全校通识课)

2017—present “从DNA到基因组”(生物医学学院本科生,全英课程)

康奈尔大学威尔太阳成集团tyc234cc和研究生院:

2006—present “Animal models for human disease” (2 hours, “Clinical and Translational Research Training Program”)

2008 Focus group “Small RNAs in development and diseases” (2 hours, Graduate School)

2008—present “Human Embryology and Development” (2 hours, Medical School)

2009—present “Histology” (30 hours, Medical School)

2010—present “Gene regulation by non-coding RNAs” (2 hours, Medical School)

2011—2012 “Frontiers in Biomedical Science” (2 hours, M.D./Ph.D. Program)

2011—present “Developmental Biology—Brain Patterning and Morphogenesis” (2 hours, Developmental Biology Training Program, Graduate School)

2012— present “miRNAs & post transcriptional regulation in Development” (2 hours, Neuroscience Program, Graduate School)

2012— present “miRNAs and human diseases” (2 hours, “Clinical and Translational Training Program”)

-应邀报告

2006 哥伦比亚大学 (Columbia University, USA)

2007 康奈尔大学 (Cornell University, Ithaca, USA)

2009 杜兰大学 (Tulane University, USA)

2011 伯克医学研究所 (Burke Medical Research Institute, USA)

2011 苏州大学

2011 上海交通大学

2012 康奈尔大学卡塔尔分校(Cornell University at Qatar)

2012 noncoding RNA in development and human diseases, Boston, USA

2012 Johnson & Johnson Stem cell meeting, New York, NY

2012 Roche Stem Cell Symposium, New York, NY

2012 “2012 Shanghai International Forum on Neuroscience”, Shanghai, China

2012 “Ellison Medical Foundation Colloquium”, Woods Hole, MA, USA

2013 Hunter College, New York, NY USA

2014 “Annual Papanicolaou Symposium”, Weill Cornell Medical College, New York,

2015 Virginia Commonwealth University, Richmond VA

2015 Texas A&M University, Bryan TX

2016 Albany Medical College, Albany, NY

-博士毕业论文指导

• Andrew Pollock (primary,已毕业)

• Rudy Bellani (primary, 已毕业)

• Aisha Abdullah (primary, 已毕业)

• Jennifer Knauss (primary, 已毕业)

• Bihui Huang (已毕业)

-博士毕业答辩委员会

Jamie Kugler (BCMB program, Weill Cornell Medical College)

Pei-Ken Hsu (Columbia University)

Andrew Pollock (primary sponsor, Weill Cornell Medical College)

Rudy Bellani (primary sponsor, Weill Cornell Medical College/ Rockefeller University)

-博士后成员

Shan Bian 2010-

Haijun Zhang 2010-

Junghee Jin 2011-

Qingsong Li 2011-

Zhenyong Huang 2005-2007 (now postdoc at Weill Cornell Medical College)

Liheng Shi 2005-2007 (now postdoc at Texas A&M University)

Yoko Koga 2005-2009 (now Assistant Professor at Tokyo University)

Laura Shebelle 2010-2011 (now a postdoc in Germany)

Gaizka Otaegi 2006-2012 (now consultant at BRG Business Research Group)

-受邀任评委情况

· 评审主编Review Editor: Frontiers in Cell and Developmental Biology.

· 主编Editor for a new book “Neural Stem Cells and Therapy” (2011), InTech.

I have worked together with 20 authors who contribute chapters to this book and reviewed all chapters.

· 主编Associate Editor: MicroRNA Journal.

· 文章评委Reviewer for: Journal of Neuroscience, Nature Neuroscience, Nature Communications, Development, BMC Neuroscience, Brain Research, Journal of Neuroscience Methods, FEBS Letters, PloS ONE, Frontiers Neurosciences, WIREs Developmental Biology, Cell Death and Differentiation, Developmental Biology.

· 课题评委Grant reviewer for:

2011-2012: AFM Foundation, France;

2011: The Wellcome Trust, UK;

2012-目前: Medical Research Council (MRC), UK;

2011-目前: 中国国家自然科学基金

2013 Netherlands Organisation for Scientific Research

2014 University of Missouri Spinal Cord Injuries Research Program (UM SCIRP)

2014 Neurological Foundation of New Zealand, New Zealand

-专利获得情况

July 24 2012

microRNA cluster that promotes neurogenesis

# 5988-01-US (31305-0013)


2015年04月13日

miR-17-92基因簇促进神经细胞增殖和神经再生的新应用

专利号:201510173294.2

-研究论文

1. Tao Sun (1995). Methods of the preparation of the chromosome from land snails. Chinese Journal of Zoology 30(6), 27-30 (in Chinese with English abstract).

2. Shui-gen Hong, Tao Sun, Zi-mian Ni and Ru Xue (1995). Studies on the spermatogenesis in Tachypleus tridentatus: I. The stages of spermatogenesis. Acta Zoologica Sinica 41(4), 393-402 (in Chinese with English abstract).

3. Tao Sun, Nigel P. Pringle, Adrain P. Hardy, William D. Richardson and Hazel K. Smith (1998). Pax6 influences the time and site of origin of glial precursors in the ventral spinal cord. Molecular and Cellular Neuroscience 12, 228-239.

4. Tao Sun, Damith Jayatilake, Gijs Afink, Paris Ataliotis, Monica Nister, William D. Richardson and Hazel K. Smith (2000). A human YAC transgene rescues craniofacial and neural tube development in PDGFRa knockout mice and uncovers a role for PDGFRa in prenatal lung growth. Development 127, 4519-4529.

5. Jose L. Mullor, Nadia Dahmane, Tao Sun and Ariel Ruiz i Altaba (2001). Wnt signals are targets and mediators of Gli function. Current Biology 11:769-73

6. Tao Sun, Yann Echelard, Richard Lu, Dong-in Yuk, Sovann Kaing, Charles D. Stiles and David H. Rowitch (2001). Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Current Biology 11:1413–1420.

7. Q. Richard Lu, Tao Sun, Zhimin Zhu, Nan Ma, Meritxell Garcia, Charles D. Stiles and David H. Rowitch (2002). Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 109, 75–86.

8. Lizi Wu, Tao Sun, Karla Kobayashi, Ping Gao, and James D. Griffin (2002). Identification of a family of mastermind-like transcriptional coactivators for mammalian Notch receptors. Molecular and Cellular Biology, 22(21):7688–7700.

9. Tao Sun, Hualing Dong, Lizi Wu, Micheal Kane, David H. Rowitch and Charles D. Stiles (2003). Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. Journal of Neuroscience. 23(29):9547-56.

10. Lizi Wu, Karla Kobayashi, Tao Sun, Ping Gao, Jingxuan Liu, Makoto Nakamura, Ellen Weisberg, Nishit Mukhopadhyay and James D. Griffin (2004). Cloning and functional characterization of the murine mastermind-like 1 (maml1) gene. Gene, 328:153-65.

11. Tao Sun, Christina Patoine, Jane Visvader, Eleanor Sum, Timothy J. Cherry, Stuart H. Orkin, Daniel H. Geschwind and Christopher A. Walsh (2005). Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science, 308(5729):1794-8. (Published online 12 May 2005).

12. Keith L. Ligon, Santosh Kesari, Masaaki Kitada, Tao Sun, Heather A. Arnett, John A. Alberta, David J. Anderson, Charles D. Stiles, and David H. Rowitch (2006). Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A. 103(20):7853-8.

13. Tao Sun, Brain Hafler, Sovann Kaing, Masaaki Kitada, Keith Ligon, Hans Widlund, Dong-in Yuk, Charles D. Stiles and David H. Rowitch (2006). Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Developmental Biology, 292(1):152-164.

14. Tao Sun, Randall V. Collura, Katherine Miller, Maryellen Ruvolo and Christopher A. Walsh (2006). Genomic and evolutionary analyses of asymmetrically expressed genes in human fetal left and right cerebral cortex. Cerebral Cortex, 16 Suppl 1:i18-25.

15. Zhenyong Huang, Yoko Kawase-Koga, Shuqun Zhang, Jane Visvader, Miklos Toth, Christopher A. Walsh and Tao Sun (2009). Transcription factor Lmo4 defines the shape of functional areas in developing cortices and regulates sensorimotor control. Developmental Biology, 327(1):132-142. Epub 2008 Dec 16.

16. Yoko Kawase-Koga, Gaizka Otaegi and Tao Sun (2009). Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Developmental Dynamics, 238:2800–2812.

17. Yoko Kawase-Koga, Roger Low, Gaizka Otaegi, Andrew Pollock, Haiteng Deng, Frank Eisenhaber, Sebastian Maurer-Stroh and Tao Sun (2010). RNAase III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells. Journal of Cell Science, 123(Pt 4):586-94.

18. Gaizka Otaegi, Andrew Pollock, Janet Hong and Tao Sun (2011). MicroRNA miR-9 modifies motor neuron columns by a tuning regulation of FoxP1 levels in developing spinal cords. Journal of Neuroscience, 31(3):809-18.

19. Qingsong Li, Shan Bian, Janet Hong , Yoko Kawase-Koga, Edwin Zhu, Yongri Zheng, Lizhuang Yang and Tao Sun (2011). Timing specific requirement of microRNA function is essential for embryonic and postnatal hippocampal development. PloS ONE, 6(10): e26000.

20. Hea-Jin Jung, Catherine Coffinier, Youngshik Choe, Anne P. Beigneux, Brandon S. J. Davies, Shao H. Yang, Richard H. Barnes II, Janet Hong, Tao Sun, Samuel J. Pleasure, Stephen G. Young and Loren G. Fong (2012) Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc Natl Acad Sci U S A. 109(7): E423-31.

21. Gaizka Otaegi, Andrew Pollock and Tao Sun(2012). An optimized sponge for microRNA miR-9 affects spinal motor neuron development in vivo. Frontiers in Neuroscience, 5:146.

22. Qingsong Li, Shan Bian, Bingfang Liu, Janet Hong, Yan Zhao, Miklos Toth and Tao Sun (2013). Establishing brain functional laterality in adult mice through unilateral gene manipulation in the embryonic cortex. Cell Research. 23(9):1147-9. PMID: 23917527; NIHMSID: 485487.

23. Shan Bian, Janet Hong, Qingsong Li, Laura Schebelle, Andrew Pollock, Vidur Garg and Tao Sun (2013). miR-17-92 miRNAs regulate expansion of radial glial cells and conversion of intermediate progenitors in the developing neocortex. Cell Reports. 3(5):1398-1406. PMID: 23623502; PMCID: PMC3762321.

24. Tomasz Jan Nowakowski, Vassiliki Fotaki, Andrew Pollock, Tao Sun, Thomas Pratt and David J. Price (2013). MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain. Proc Natl Acad Sci U S A. 110(17):7056-61. PMID: 23569256.

25. Janet Hong, Haijun Zhang, Yoko Kawase-Koga and Tao Sun (2013). MicroRNA function is required for neurite outgrowth of mature neurons in the mouse postnatal cerebral cortex. Frontiers in Cellular Neurosciences. 7:151. PMID: 24062642.

26. Jennifer L. Knauss, Shan Bian and Tao Sun (2013). Plasmid-based target protectors allow specific blockade of miRNA silencing activity in mammalian developmental systems. Frontiers in Cellular Neurosciences. 7:163. PMID: 24068984.

27. Andrew Pollock, Shan Bian, Chao Zhang, Zhengming Chen, Tao Sun (2014). Growth of the developing cerebral cortex is controlled by microRNA-7 through the p53 pathway. Cell Reports. 7(4):1184-96. PMID: 24813889.

28. Yase Chen, Shan Bian, Jing Zhang, Haijun Zhang, Beisha Tang and Tao Sun (2014). The silencing effect of microRNA miR-17 on p21 maintains the neural progenitor pool in the developing cerebral cortex. Frontiers in Neurology. 5:132. PMID: 25101050, PMCID: PMC4103084.

29. Haijun Zhang, Yoko Kawase-Koga and Tao Sun (2015). Protein Expression Profiles Characterize Distinct Features of Mouse Cerebral Cortices at Different Developmental Stages. PLoS One. 10(4):e0125608. PMID: 25915664.

30. Aisha I. Abdullah, Haijun Zhang, Yanzhen Nie, Wei Tang and Tao Sun (2016). CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex. Stem Cell Reports. 7(1):69-79. PMID: 27411104, PMCID: PMC4944761.

31. Junghee Jin, Seung-Nam Kim, Xuqing Liu, Haijun Zhang, Chao Zhang, Ji-Seon Seo, Yong Kim, Tao Sun (2016). miR-17-92 Cluster Regulates Adult Hippocampal Neurogenesis, Anxiety, and Depression. Cell Reports. 16(6):1653-63. PMID: 27477270, PMCID: PMC4981532.

32. Nan Miao, Junghee Jin, Seung-Nam Kim, Tao Sun (2018). Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice. International Journal of Molecular Sciences. 19(3), 671. PMID: 29495532.

33. Haijun Zhang, Longbin Zhang, Tao Sun (2018). Cohesive Regulation of Neural Progenitor Development by microRNA miR-26, Its Host Gene Ctdsp and Target Gene Emx2 in the Mouse Embryonic Cerebral Cortex. Frontiers in Molecular Neuroscience. 11:44. PMID: 29515367 PMCID: PMC5825903.

34. Nan Miao, Shan Bian, Trevor Lee, Taufif Mubarak, Shiying Huang, Zhihong Wen, Ghulam Hussain and Tao Sun (2018). Opposite roles of Wnt7a and Sfrp1 in modulating proper development of neural progenitors in the mouse cerebral cortex. Frontiers in Molecular Neuroscience. 11:247. PMID: 30065628.

35. Junghee Jin, Heejae Ko, Tao Sun and Seung-Nam Kim (2018). Distinct function of miR-17-92 cluster in the dorsal and ventral adult hippocampal neurogenesis. Biochemical and Biophysical Research Communications. 503(3):1594-1598. PMID: 30054043.

36. Longbin Zhang, Taufif Mubarak, Yase Chen, Trevor Lee, Andrew Pollock and Tao Sun (2018). Counter-Balance Between Gli3 and miR-7 Is Required for Proper Morphogenesis and Size Control of the Mouse Brain. Frontiers in Cellular Neuroscience. 12:259. PMID: 30210296.

37. Haijun Zhang, Yafei Chang, Longbin Zhang, Seung-Nam Kim, Gaizka Otaegi, Zhen Zhang, Yanzhen Nie, Taufif Mubarak, Cui Li, Cheng-Feng Qin, Zhiheng Xu and Tao Sun (2018). Upregulation of MicroRNA miR-9 Is Associated with Microcephaly and Zika Virus Infection in Mice. Molecular Neurobiology. 56(6):4072-4085. PMID: 30264295.

38. Jennifer L. Knauss, Nan Miao, Seung-Nam Kim, Yanzhen Nie, Yuelin Shi, Tao Wu, Hugo Borges Pinto, Mary E. Donohoe and Tao Sun (2018) Long noncoding RNA Sox2ot and transcription factor YY1 co-regulate differentiation of cortical neural progenitors by repressing Sox2. Cell Death and Disease. 9(8):799. PMID: 30038234.

39. Yanxia Gao, Jiaheng Li, Zhen Zhang, Ruihan Zhang, Andrew Pollock and Tao Sun (2019) MicroRNA miR-7 and miR-17-92 in the Arcuate Nucleus of Mouse Hypothalamus Regulate Sex-Specific Diet-Induced Obesity. Molecular Neurobiology. 56(11):7508-7521. PMID: 31044367.

40. Nan Miao, Xiaodong Lai, Zhiwei Zeng, Wenjie Cai, Wanhua Chen and Tao Sun (2020) Differential expression of microRNAs in the human fetal left and right cerebral cortex. Molecular Biology Reports. 47, 6573–6586. PMID: 32808117.

41. Longbin Zhang, Kunzhao Du, Jing Wang, Yanzhen Nie, Trevor Lee and Tao Sun (2020) Unique and Specific m6A RNA Methylation in Mouse Embryonic and Postnatal Cerebral Cortices. Genes (Basel). 11(10):1139. PMID: 32992647.

42. Yanzhen Nie, Geng G Tian, Longbin Zhang, Trevor Lee, Zhen Zhang, Jing Li, Tao Sun (2020) Identifying cortical specific long noncoding RNAs modified by m6A RNA methylation in mouse brains. Epigenetics.1-17. PMID: 33323036.

43. Zhen Zhang, Na Li, Renliang Chen, Trevor Lee, Yanxia Gao, Zhongyu Yuan, Yanzhen Nie, Tao Sun (2021) Prenatal stress leads to deficits in brain development, mood related behaviors and gut microbiota in offspring. Neurobiology of Stress. 15:100333. PMID: 34036126; PMCID: PMC8135039.

44. Kunzhao Du, Zhen Zhang, Zhiwei Zeng, Jinling Tang, Trevor Lee, Tao Sun (2021) Distinct roles of Fto and Mettl3 in controlling development of the cerebral cortex through transcriptional and translational regulations. Cell Death & Disease. 12(7):700. PMID: 34262022; PMCID: PMC8280107.

45. Yuan Yu, Zhiwei Zeng, Danlin Xie, Renliang Chen, Yongqiang Sha, Shiying Huang, Wenjie Cai, Wanhua Chen, Wenjun Li, Rongqin Ke, Tao Sun (2021) Interneuron origin and molecular diversity in the human fetal brain. Nature Neuroscience. 24(12): 1745-1756. PMID: 34737447

46. Jing Wang, Zixi Chen, Fei He, Trevor Lee, Wenjie Cai, Wanhua Chen, Nan Miao, Zhiwei Zeng, Ghulam Hussain, Qingwei Yang, Qiwei Guo, Tao Sun (2022) Single-Cell Transcriptomics of Cultured Amniotic Fluid Cells Reveals Complex Gene Expression Alterations in Human Fetuses With Trisomy 18. Frontiers in Cell and Developmental Biology. 10: 825345. PMID: 35392164.

47. Nan Miao, Wenjie Cai, Sijia Ding, Yajuan Liu, Wanhua Chen, Tao Sun (2022) Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma. Molecular Medicine Reports. 26(3):287. PMID: 35894132.

48. Yongqiang Sha, Huhai Hong, Wenjie Cai, Tao Sun (2022) Single-Cell Transcriptomics of Endothelial Cells in Upper and Lower Human Esophageal Squamous Cell Carcinoma. Current Oncology. 29(10):7680-7694. PMID: 36290884

49. Nan Miao, Zhiwei Zeng, Trevor Lee, Qiwei Guo, Wenwei Zheng, Wenjie Cai, Wanhua Chen, Jing Wang, Tao Sun (2023) Integrative epigenome profiling of 47XXY provides insights into whole genomic DNA hypermethylation and active chromatin accessibility. Frontiers in Molecular Biosciences. 10:1128739. PMID: 37051325.

50. Chenlin Zheng, Chao Tu, Jing Wang, Yuan Yu, Xueyu Guo, Jason Sun, Julianne Sun, Wenjie Cai, Qingwei Yang, Tao Sun (2023) Deciphering Oligodendrocyte Lineages in the Human Fetal Central Nervous System Using Single-Cell RNA Sequencing. Molecular Neurobiology. doi: 10.1007/s12035-023-03661-9. PMID: 37775719.

-专著与综述

1. Tao Sun, Ming Zhao and Lian-feng Zhang (1996). Homeobox genes and the development. Overseas Medicine, Genetics Section 19(1), 38-40 (minireview in Chinese).

2. Tao Sun and Xue-feng Liu (1996). Isolation of specifically expressed genes by differential display. Progress in Biochemistry and Biophysics 23(4), 316-318 (review in Chinese with English abstract).

3. William D. Richardson, Hazel K. Smith, Tao Sun, Nigel P. Pringle, Anita Hall and Rachel Woodruff (2000). Oligodendrocyte lineage and the motor neuron connection. Glia 29, 136-142.

4. Tao Sun and Christopher A. Walsh (2006). Molecular approaches to brain asymmetry and handedness. Nature Reviews Neuroscience, 7(8):655-662.

5. Tao Sun (2010). Differential gene transcription in the left and right cerebral cortex. "The two halves of the brain: Information processing in the cerebral hemispheres". The MIT Press. P21-36.

6. Shan Bian and Tao Sun (2011). Functions of noncoding RNAs in neural development and neurological diseases. Molecular Neurobiology. 44(3):359-73. Epub 2011 Oct 4.

7. Shan Bian and Tao Sun (2012). Noncoding RNAs in Neural Stem Cell Development. “Neural Stem Cells and Therapy”. The InTech Open Access Publisher.

8. Aisha Abdullah, Andrew Pollock and Tao Sun (2012). The Path from Skin to Brain: Generation of Functional Neurons from Fibroblasts. Molecular Neurobiology. 45(3):586-95.

9. Tao Sun and Quan-hong Ma (2013). Repairing neural injuries using human umbilical cord blood. Molecular Neurobiology 47(3):938-45.

10. Haijun Zhang, Benjamin Shykind and Tao Sun (2012) Approaches to manipulating microRNAs in neurogenesis. Frontiers in Neuroscience. 6:196.

11. Jennifer L. Knauss and Tao Sun (2013). Regulatory mechanisms of long noncoding RNAs in neural development and function. Neuroscience. 235:200-14. PMID: 23337534; PMCID: PMC3595319.

12. Michał Harciarek, Dolores Malaspina, Tao Sun and Elkhonon Goldberg (2013). Schizophrenia and frontotemporal dementia: Shared causation? International Review of Psychiatry. 25(2):168-77. PMID: 23611347.

13. Shan Bian, Tian-le Xu and Tao Sun (2013). Tuning the cell fate of neurons and glia by microRNAs. Current Opinion in Neurobiology. 23(6):928-34. PMID: 23978589; NIHMSID: 519154.

14. Tao Sun and Robert Hevner (2014). Growth and Folding of the Mammalian Cerebral Cortex, from Molecules to Malformations. Nature Reviews Neuroscience. 15(4):217-234.

15. Xuqing Liu and Tao Sun (2016). microRNAs and Molecular Pathogenesis of Microcephaly. Current Molecular Pharmacology. 9(4):300-304. PMID: 26415911

16. Yanxia Gao and Tao Sun (2016). Molecular regulation of hypothalamic development and physiological functions. Molecular Neurobiology. 53(7):4275-85. PMID: 26223804 PMCID: PMC4733441

17. Gabriele Floris, Longbin Zhang, Paolo Follesa and Tao Sun (2017). Regulatory Role of Circular RNAs and Neurological Disorders. Molecular Neurobiology. 54(7):5156-5165. PMID: 27558238

18. Ghulam Hussain, Longbin Zhang, Azhar Rasul, Haseeb Anwar, Muhammad Umar Sohail, Aroona Razzaq, Nimra Aziz, Asghar Shabbir, Muhammad Ali and Tao Sun (2018). Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer’s and Parkinson’s Diseases: An Update of Recent Data. Molecules. 23(4), 814. PMID: 29614843

19. Kunzhao Du, Longbin Zhang, Trevor Lee and Tao Sun (2018). m6A RNA Methylation Controls Neural Development and Is Involved in Human Diseases. Molecular Neurobiology. 56(3):1596-1606. PMID: 29909453

20. Zhiwei Zeng, Nan Miao and Tao Sun (2018). Revealing cellular and molecular complexity of the central nervous system using single cell sequencing. Stem Cell Research & Therapy. 9(1):234. PMID: 30213269

21. Ghulam Hussain, Jing Wang, Azhar Rasul, Haseeb Anwar, Ali Imran, Muhammad Qasim, Shamaila Zafar, Syed Kashif Shahid Kamran, Aroona Razzaq, Nimra Aziz, Waseem Ahmad, Asghar Shabbir, Javed Iqbal, Shahid Mahmood Baig and Tao Sun. (2019) Role of cholesterol and sphingolipids in brain development and neurological disease. Lipids in Health and Disease. 18(1):26. PMID: 30683111.

22. Yuanyuan Sun, Nan Miao and Tao Sun (2019) Detect accessible chromatin using ATAC-sequencing, from principle to applications. Hereditas. 156:29. PMID: 31427911.

23. Ghulam Hussain, Jia Huang, Azhar Rasul, Haseeb Anwar, Ali Imran, Javeria Maqbool, Aroona Razzaq, Nimra Aziz, Ehtisham ul Haq Makhdoom, Muhsin Konuk and Tao Sun (2019) Putative Roles of Plant-Derived Tannins in Neurodegenerative and Neuropsychiatry Disorders: An Updated Review. Molecules. 24(12). PMID: 31200495.

24. Ghulam Hussain, Jing Wang, Azhar Rasul, Haseeb Anwar, Muhammad Qasim, Shamaila Zafar, Nimra Aziz, Aroona Razzaq, Rashad Hussain, Jose-Luis Gonzalez de Aguilar and Tao Sun (2019) Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery. International Journal of Biological Sciences. 16(1):116-134. PMID: 31892850.

25. Jinling Tang, Trevor Lee and Tao Sun (2019) Single nucleotide editing: From principle, optimization to application. Human Mutation. 40(12):2171-2183. PMID: 31131955.

26. Zhiwei Zeng, Shi-Ying Huang and Tao Sun (2020) Pharmacogenomic Studies of Current Antidiabetic Agents and Potential New Drug Targets for Precision Medicine of Diabetes. Diabetes Therapy. 11, 2521–2538. PMID: 32930968.

27. Zhong Chen, Javeria Maqbool, Faiqa Sajid, Ghulam Hussain, Tao Sun (2020) Human gut microbiota and its association with pathogenesis and treatments of neurodegenerative diseases. Microbial Pathogenesis. 150:104675. PMID: 33352217.

28. Jing Wang, Yongqiang Sha and Tao Sun (2021) m6A modifications play crucial roles in glial cell development and brain tumorigenesis. Frontiers in Oncology. 11:611660. PMID: 33718165; PMCID: PMC7943831.

29. Wenxin Wang and Tao Sun (2024) Impact of TRPV1 on Pathogenesis and Therapy of Neurodegenerative Diseases. Molecules. 29(1): 181. PMID: 38202764.

30. Yikai Chen, Julianne Sun, Junxian Tao, Tao Sun (2024) Treatments and regulatory mechanisms of acoustic stimuli on mood disorders and neurological diseases. Frontiers in Neuroscience. 17:1322486. PMID: 38249579.

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